But he has seemingly been able to put the controversy behind him, manoeuvring his way through tough tests against Britain's Jack Draper and 2021 champion Medvedev.
"My aunt is not feeling well health-wise and I don't know how much longer I have her in my life," he said.
The 26-year-old recovered well to win three games in a row, but he continued to falter on serve and Sinner capitalised to take the opener and subdue the expectant mood on Arthur Ashe Stadium.
"If there was a wish I could make, I would wish good health on everyone but unfortunately it's not possible."
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Refusing to dwell on the first set, Fritz improved and made the second a closer affair, losing just two points in four service games.
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England interim boss Lee Carsley says their win over the Republic of Ireland has boosted his confidence - admitting he had doubts about his ability to do the job.
Having failed to make the most of three break point opportunities early in the third set, Fritz brought the crowd to life with two brilliant winners to break for a 4-3 lead and keep alive his hopes.
It has been nearly 50 years since a man won their first and second Grand Slam titles in the same season, and Sinner is now a long way clear of the rest at the top of the rankings.
It 星空体育官网 comes just 19 days after it was revealed he had been cleared of any wrongdoing after twice testing positive for a banned substance in March.
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Just six days before the main draw got under way, it was announced he had twice tested positive for low levels of a metabolite of clostebol - a steroid that can be used to build muscle mass - in March.
It marks a new era of tennis as 24-time major winner Novak Djokovic, who was knocked out in the third round, ends the year without a Grand Slam title for the first time since 2017.
He subsequently parted ways with the physio and his fitness trainer - but questions continued about whether Sinner's case had been handled differently to those of other players because of his world number one status.
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The 23-year-old held his arms aloft and looked up to the sky as he became the first player since Guillermo Vilas in 1977 to win his first two Grand Slam titles in the same season.
La Kings League InfoJobs está do vuelta para su cuarto Split, de que lançará comienzo en el Cupra Arena el próximo 15 por septiembre. Tras la celebración por unos 'tryouts' innovadores para conocer los jugadores que podrán ser elegidos en el próximo draft del día 11, fecha en la que se volverá a poder negociar fichajes y rondas de modo a acabar do definir las plantillas, ya queda tan solo una semanada para qual el balón empiece a rodar.